Product Name

Cathepsin D from human liver

Assay

≥250 units/mg protein (E1%/280)

CAS Number

9025-26-7

Molecular Weight

mol wt ~45 kDa

MDL number

MFCD00130749

Suitability

BioReagent

l Physical and Chemical Information

Appearance

White lyophilized powder

Physical form

Powder containing sodium phosphate buffer salt.

l Biological Information

Biochem/Physiol Actions

Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.

Unit Definition

One unit will produce an increase in A₂₈₀ of 1.0 in 30 min at pH 3.3 at 37 °C measured as TCA-soluble products using acid-denatured hemoglobin as substrate (1 cm light path).

l Storage

Storage temp.

-20°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov