Product Name

Factor V Activating Enzyme from Russell's viper venom

Assay

20 units/mg protein

CAS Number

65522-14-7

MDL number

MFCD00166484

Suitability

BioReagent

l Physical and Chemical Information

Appearance

lyophilized powder

Physical form

Stabilized in albumin and sodium chloride.

l Biological Information

Biochem/Physiol Actions

Factor V activator for RVV contains fucose, mannose, galactose, glucosamine, and neuraminic acid. Factor V activating enzyme from RVV is an arginine esterase that is sensitive to diisopropyl fluorophosphate (DFP) .

Application

Factor V activating enzyme from Russell’s viper venom (RVV) is a single-chain glycoprotein that is involved in the rapid clotting of blood. Factor V circulates in the blood as an inactive cofactor and must be activated by proteases such as Factor V activating enzyme from RVV . This product may be useful in studying the blood coagulation cascade as well as the inherited deficiency called parahemophilia .

Preparation Note

Stabilized in albumin and sodium chloride.

Unit Definition

One unit will increase the Factor V activity in 0.1 mL of fresh normal human plasma by at least 2× after incubation for 3 min at 37 °C.

l Storage

Storage temp.

-20°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov