Product Name

Protein C from human plasma

Synonym

Activated Protein C

Assay

Activated, ≥90% (SDS-PAGE)

CAS Number

42617-41-4

Molecular Weight

heavy chain mol wt 41 kDa; light chain mol wt 21 kDa

MDL number

MFCD00165567

Suitability

BioReagent

l Physical and Chemical Information

Appearance

White lyophilized powder

Physical form

Lyophilized powder from 20 mM Tris-HCl, pH 7.4, containing 0.1 M NaCl

Solubility(25°C)

H²O: 1 mg/mL

l Biological Information

Biochem/Physiol Actions

In addition, activated protein C has been shown to inhibit TNF-α induced  of the inflammatory proteins VCAM, ICAM-I, and Ilk-8 in endothelial cells.

Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa. The Protein C anticoagulant pathway is triggered when thrombin binds to the endothelial cell proteoglycan, thrombomodulin. This complex, which cannot clot blood, is a potent activator of the protein C zymogen. Activation involves the release of a dodecapeptide from the N-terminal domain of the heavy chain. The activated Protein C (APC) then binds to protein S on cell surfaces and inactivates the coagulation factors Va and VIIIa by proteolysis. APC has also been shown to bind to receptors on the endothelium of large blood vessels.

Protein C is a plasma, vitamin κ-dependent zymogen of a serine protease that can inhibit blood coagulation by inhibiting thrombin formation, selectively inactivating Factors Va and VIIIa.

Preparation Note

Lyophilized powder from 20 mM Tris-HCl, pH 7.4, containing 0.1 M NaCl

l Storage

Storage temp.

-20°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov