Product Name

Thrombin from human plasma

General deion

Lyophilized powder containing sucrose, sodium chloride and Tris. Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects.

Synonym

Factor Iia

Assay

400-1000 NIH units/mg protein

CAS Number

9002-04-4

MDL number

MFCD00082072

Suitability

BioReagent

l Physical and Chemical Information

Appearance

White to Off White lyophilized powder

l Biological Information

Biochem/Physiol Actions

Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.

Application

Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study to assess an innovative flow cytometric approach for small-size platelet microparticles.

Unit Definition

Activity is expressed in NIH units obtained by direct comparison to a NIH Thrombin Reference Standard

l Storage

Storage temp.

-20°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov