Product Name

Thrombin from bovine plasma

General deion

Thrombin is the final coagulation protease in regard to hemostasis, promoting both procoagulant and anticoagulant effects.

Synonym

Factor Iia

Assay

40-300 NIH units/mg protein (biuret); Protein, 40-60%

CAS Number

9002-04-4

MDL number

MFCD00166053

Suitability

BioReagent

l Physical and Chemical Information

Appearance

White to Off-White lyophilized powder

Physical form

Lyophilized powder containing sodium chloride and Tris-HCl, pH 7.0

l Biological Information

Biochem/Physiol Actions

Serine protease that selectively cleaves Arg-Gly bonds in fibrinogen to form fibrin and fibrinopeptides A and B.

Application

Thrombin is used for site specific cleavage of recombinant fusion proteins containing an accessible thrombin recognition site for removal of affinity tags. Thrombin has been used in a study to assess persistent hypocoagulability in patients with septic shock.

Preparation Note

Lyophilized powder containing sodium chloride and Tris-HCl, pH 7.0. Activated with bovine brain thromboplastin.

l Storage

Storage temp.

-20°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov