Product Name

Dipeptidyl Peptidase VII human

Synonym

DPP7, Quiescent cell proline dipeptidase

Assay

recombinant, expressed in Sf9 cells; ≥1,500 units/μg protein

Suitability

BioReagent

l Physical and Chemical Information

Physical form

Supplied as a solution in 25 mM Tris-HCl, pH 8.0, 130 mM NaCl, 0.05% Tween-20, 10% glycerol.

l Biological Information

Biochem/Physiol Actions

DPP7 is essential for maintaining lymphocytes and fibroblasts in G(0). The inhibition of DPP7 results in apoptosis, which is mediated by the induction of c-Myc and p53. DPP7 has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH.

Application

Dipeptidyl Peptidase VII (DPP7), also known as DPP2 or quiescent cell proline dipeptidase, is a post-proline cleaving aminopeptidase that is expressed in quiescent lymphocytes. DPP7 is used to study the regulation of cell quiescence . Like DPP4, DPP7 may be useful in diabetes and vascular disease research.

Unit Definition

One unit will hydrolyze 1.0 picomole of Ala-Pro-AMC per minute at pH 7.4 at 25 deg °C

l Storage

Storage temp.

−70°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov