Product Name

Leukotriene A₄ Hydrolase human

Synonym

LTA-4 hydrolase, LTA4, LTA⁴H

Assay

recombinant, expressed in E. coli; ≥90% (SDS-PAGE)

CAS Number

90119-07-6

Molecular Weight

mol wt ~69 kDa

MDL number

MFCD08460576

Suitability

BioReagent

l Physical and Chemical Information

Physical form

Supplied as a solution in 100mM Tris, pH 8.0, containing 20% glycerol and 100mM potassium chloride.

l Biological Information

Biochem/Physiol Actions

Leukotriene A⁴ Hydrolase human (LTA⁴H) is a bifunctional zinc metalloenzyme that converts LTA4 into Leukotriene B4, and also demonstrates aminopeptidase activity. Leukotriene B4 is a lipid chemoattractant that plays critical roles in inflammaton, immune responses, host defenses against infections, and lipid homeostasis. Inhibition of LTA⁴H in a mouse model decreases LTB⁴ in the airways and attenuates airway inflammation and airway hyperreactivity through modulation of T cell and dendritic cell function.

Application

Leukotriene A⁴ Hydrolase human (LTA⁴H) is a drug target for anti-inflammation, and for cancer prevention and therapy. It is also suitable for screening inhibitors of Leukotriene B4 synthesis. LTA⁴H is used to study allergic asthma and airway hyperresponsiveness.

l Storage

Storage temp.

−70°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov