Product Name

Restrictocin from Aspergillus restrictus

MDL number

MFCD00213039

Suitability

BioReagent

l Physical and Chemical Information

Appearance

lyophilized powder

Physical form

Lyophilized from 0.3 mL of 0.5% NaCl

l Biological Information

Biochem/Physiol Actions

Restrictocin from Aspergillus restrictus is a ribosome-inactivating protein that acts by specifically cleaving rRNA. Approximately 70% of the protein is active restrictocin. Restrictocin shares a high degree of amino acid sequence homology with mitogillin, a ribotoxin that cleaves a single phosphodiester bond of the 29S rRNA of eukaryotic ribosomes . Restrictocin is thought to be activated during the process of secretion .

Application

Restrictocin from Aspergillus restrictus is used to inhibit protein synthesis. It may be useful as a component of immunotoxins . Product R0389 is provided as a lyophilized powder.

l Storage

Storage temp.

−20°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov