l General Information |
Product Name | Hck human |
Assay | ≥200 units; recombinant, expressed in E. coli BL21, vial of; 1-2 unit/μg protein |
MDL number | MFCD03792313 |
Suitability | BioReagent |
l Physical and Chemical Information |
Physical form | Supplied as a solution in 50 mM Tris HCl, pH 7.4, 1 mM EDTA and 1 mM DTT |
l Biological Information |
Biochem/Physiol Actions | Hck is a member of the Src tyrosine kinase family. Hck has been shown to associate with and be activated by Bcr-Abl, which is a protein-tyrosine kinase that is expressed in chronic myelogenous leukemia . |
Application | Hck is a protein-tyrosine kinase that is expressed in hemopoietic cells. It is used in leukemia research . |
Unit Definition | One unit will phosphorylate 1.0 picomole of Tyr15 of the peptide substrate pcdc2 6-20 per minute at 30 °C at pH 7.4. |
l Storage |
Storage temp. | −70°C |
l Precautions and Disclaimer |
This product is for R&D use only, not for drug, household, or other uses. |
l References |
1. http://www.drugbank.ca 2. https://ncit.nci.nih.gov 3. https://www.ncbi.nlm.nih.gov |
