Product Name

Cyclin-Dependent Kinase 5 human

Assay

50-100 units/μg protein; recombinant, expressed in E. coli BL21

MDL number

MFCD06201997

Suitability

BioReagent

l Physical and Chemical Information

Physical form

Supplied as a solution in PBS pH 7.4, 1 mM EDTA, 1mM DTT and 1 mg/ml BSA

l Biological Information

Biochem/Physiol Actions

CDK5 is highly expressed in the nervous system where it phosphorylates a multitude of substrates. CDK5 plays an important role in many processes such as: apoptosis, phototransduction, dopamine and glutamate signalling, neurite outgrowth, neurone migration, induction of acetylcholine receptors, golgi membrane traffic and insulin exocytosis. It has also been implicated in the pathogenesis of amyotrophic lateral sclerosis . It is activated by p35 and p39, and their proteolytic cleavage products, p25 and p29.

Application

Human cyclin-dependent kinase 5 has been used in a study to determine its 3’ untranslated region subunit 1 contains regulatory elements that affect tran stability.

Unit Definition

One unit will phosphorylate 1.0 picomole of the peptide substrate histone H19-18 per minute at 30 °C at pH 7.4.

l Storage

Storage temp.

−70°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov