Product Name

Galactose-1-phosphate Uridyltransferase from galactose-adapted yeast

Synonym

GALT, UDP glucose:α-D-galactose-1-phosphate uridyltransferase

Assay

20-60 units/mg protein (modified Warburg-Christian); Type IV

CAS Number

9016-11-9

MDL number

MFCD00131120

Suitability

BioReagent

l Physical and Chemical Information

Appearance

lyophilized powder,

Physical form

Contains buffer salts as citrate and reduced glutathione

l Biological Information

Biochem/Physiol Actions

Galactose-1-phosphate uridyltransferase (GALT) facilitates the simultaneous conversion of uridine diphosphoglucose (UDP-glucose) and galactose-1-phosphate (gal-1P) to uridine diphosphogalactose (UDP-galactose) and glucose-1-phosphate. Classic Galactosemia (CG) is an inherited metabolic condition caused by deficiency of GALT activity.

Unit Definition

One unit will form 1.0 μmole of glucose 1-phosphate from UDP-glucose, galactose 1-phosphate and NADP+ per min at pH 8.7 at 25 °C as detected by a coupled system using phosphoglucomutase.

l Storage

Storage temp.

-20°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov