Product Name

S-methyl-5′-thioadenosine phosphorylase human

Assay

≥80% (SDS-PAGE)

Suitability

BioReagent

l Physical and Chemical Information

Physical form

Supplied as a solution in 25 mM Tris-HCl, pH 8.0,100 mM NaCl, 0.05% Tween®-20, 10% glycerol,and 3 mM DTT.

l Biological Information

Biochem/Physiol Actions

MTAP  is crucial for the catabolism of methylthioadenosine, which is a by-product of polyamine biosynthesis in the methionine salvage pathway. Protein  is decreased by homozygous deletion and promoter hypermethylation .

Application

S-methyl-5′-thioadenosine phosphorylase human (MTAP) is an enzyme used in cancer research that is deficient in many types of cancer. Decreased MTAP may be used as a potential indicator of disease progression of gastrointestinal stromal tumors. MTAP may be a used to develop potential therapeutic strategies for hepatocellular carcinoma (HCC) since MTAP inactivation has been ed to HCC development and invasiveness.

l Storage

Storage temp.

−70°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov