Product Name

Carnitine Acetyltransferase from pigeon breast muscle

Synonym

Acetyl-Co-A:carnitine-O-acetyltransferase, CrAT

Assay

≥50 units/mg protein

CAS Number

9029-90-7

MDL number

MFCD00130725

Suitability

BioReagent

l Physical and Chemical Information

Appearance

ammonium sulfate suspension

Physical form

Crystalline suspension in 3.2 M (NH⁴)²SO⁴ solution, 50 mM potassium phosphate, 1 mM dithiothreitol, pH 7.0

l Biological Information

Biochem/Physiol Actions

Carnitine acetyltransferase maintains the cellular and mitochondrial levels of acetyl-CoA, a key cofactor required for oxidative metabolism, by catalyzing an equilibrium between acetyl-CoA and acetyl-L-carnitine, a storage form of activated acetate. Carnitine acetyltransferase also maintains the pool of acetyl-CoA required for neuronal and nonneuronal acetylcholine production.

Unit Definition

One unit will convert 1.0 μmole of acetyl-L-carnitine and CoA to L-carnitine and acetyl-CoA per min at pH 8.0 at 25 °C.

l Storage

Storage temp.

2-8°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov