Product Name

Cytochrome P450 Reductase from rabbit liver induced with phenobarbital

Synonym

NADPH:Ferrihemoprotein oxidoreductase

Assay

~90% (SDS-PAGE);

15-45 units/mg protein (Bradford)

CAS Number

9039-06-9

Molecular Weight

mol wt ~80 kDa

MDL number

MFCD01093329

Suitability

BioReagent

l Physical and Chemical Information

Appearance

Pale Yellow to Yellow buffered aqueous glycerol solution

Physical form

Solution in 30 mM potassium phosphate buffer, pH 7.7, and 0.1 mM EDTA containing 50%(v/v) glycerol.

l Biological Information

Biochem/Physiol Actions

The enzyme catalyses electron transfer to cytochrome P450. This system plays a major role in detoxification of drugs and xenobiotics, activation of carcinogens, and metabolism of endogenous substrates such as steroids.

Unit Definition

One unit will catalyze the reduction of 1.0 μmole of cytochrome c by NADPH per min at pH 7.7 at 30 °C.

l Packaging & Storage

Storage temp.

-20°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov