Product Name

Monoamine Oxidase B human

General deion

Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs.

Synonym

MAO-B

Assay

~2.5 mg per vial; Protein: ≥2.5mg/ml; Activity: ≥1 units/mg protein;recombinant, expressed in baculovirus infected BTI insect cells

MDL number

MFCD04040933

Suitability

BioReagent

l Biological Information

Biochem/Physiol Actions

MAO’s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.

Application

Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression. Monoamine Oxidase B has been used in a study to assess the effect of age in 23 different regions of the human brain. It has also been used in a study to determine the specific locations of monoamine oxidase in the human brain.

Preparation Note

It is recommended that the product be thawed rapidly in a 37 °C water bath and kept on ice until use.

l Storage

Storage temp.

The product ships on dry ice and it is recommended to store the product at -70 °C. Avoid repeated freeze-thaw cycles.

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov