Product Name

Kynurenine 3-Monooxygenase, Pseudomonas fluorescens (strain 17400), Recombinant

Synonym

KMO

Concentration

≥ 5 mg/ml

Specific Activity

≥ 3UN/mg

Suitability

BioReagent

l Physical and Chemical Information

Appearance

solution

l Biological Information

Biochem/Physiol Actions

Kynurenine 3-monooxygenase (KMO) is a flavoprotein aromatic hydroxylase (FAH) that catalyzes the hydroxylation of L-kynurenine (L-Kyn) to produce 3-hydroxykynurenine (3-OH-Kyn). This activity is central to tryptophan metabolism and also to the production of nicotinamide adenine dinucleotide (NAD) in higher organisms. KMO contains flavin adenine dinucleotide (FAD) as a non-covalent, but tightly bound, co-factor at a 1:1 ratio of co-factor to protein.

Unit Definition

One unit will oxidize L-kynurenine at 1#·mol/min at pH 7.0, 25#ºC

l Storage

Storage temp.

The recommended long-term storage temperature for the product is –70 °C.

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov