Product Name

Xanthine Oxidase from bovine milk

General deion

Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids.

Synonym

XOD, Xanthine:oxygen oxidoreductase

Assay

≥0.1 units/mg protein

CAS Number

9002-17-9

MDL number

MFCD00082145

Suitability

BioReagent

l Physical and Chemical Information

Appearance

ammonium sulfate suspension

l Biological Information

Biochem/Physiol Actions

Although xanthine oxidase is found widely distributed in multiple tissues, it is highly expressed in endothelial and epithelial cells. Its  was also increased in infected tissues where it was shown to have an anti-microbial effect due to its ability to generate reactive oxygen species.Xanthine oxidase is a molybdenum-containing enzyme that is found in the cytosol, and may be strongly inhibited by flavonoids. It plays a vital role in the metabolism of some drugs, as well as purines and pyrimidines. It is also known to be a biological source of reactive oxygen species.

Unit Definition

One unit will convert 1.0 μmole of xanthine to uric acid per min at pH 7.5 at 25 °C. Approx. 50% of the activity is obtained with hypoxanthine as substrate.

l Storage

Storage temp.

2-8°C

l Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l References

1. http://www.drugbank.ca

2. https://ncit.nci.nih.gov

3. https://www.ncbi.nlm.nih.gov