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Home > Products > Life sciences > Enzymes and proteins > Nitroreductase from Escherichia coli

Nitroreductase from Escherichia coli

Product #: S0001
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l  General Information

Product Name

Nitroreductase from Escherichia coli

General description

Nitroreductases can play a crucial role in redox systems via NADPH or NADH as a reductant.


≥90%(SDS-PAGE), recombinant, expressed in E. coli

Molecular Weight

monomer mol wt 24000

MDL number




l  Physical and Chemical   Information


Faint Yellow to Yellow Powder

l  Biological Information

Biochem/Physiol   Actions

Nitroreductase increases the sensitivity of organisms to nitro-containing drugs such as metronidazole by converting the nitro group to a cytotoxic nitro radical.Shows ability to reduce quinines. Enzyme for activating prodrugs in antibody directed enzyme prodrug therapy.


Nitroreductase has been used in a study that used a set of PCR primers to clone a gene encoding a hypothetical nitroreductases (named as Ssap-NtrB) from uropathogenic staphylococcus. It has also been used to improve prodrug activation. Nitroreductase from Escherichia coli has been used in a study to assess anaerobic bacteria as a gene delivery system for cancer treatment. It has also been used in a study to investigate its applications in antibody-directed enzyme prodrug therapy.

Preparation   Note

Produced using animal component-free materials.

Unit   Definition

One unit will reduce one μmole of Cytochrome C per minute in the presence of Menadione and NADH at pH 7.4 at 37 °C.

l  Storage

Storage   temp.


l  Precautions and Disclaimer

This product is for R&D use only, not for drug, household, or other uses.

l  References